Ameliorative effect of hydroethanolic leaf extract of byrsocarpus. Connaraceae is a scandent shrub widely employed as a medicinal remedy for various disease conditions in west africa. The raphanus is a greek word which means quickly appearing. Raju ratan wadekar, radhika sachin supale, kunal mahesh tewari, kalpana s. The antiinflammatory effect of the aqueous leaf extract of byrsocarpus coccineus was evaluated using the carrageenan and egg albumin induced rat paw edema, xylene induced mouse ear edema and. Yoruba names for herbs and plants nigerian medicine. The ones marked may be different from the article in the profile. The leaves of byrsocarpus coccineus were carefully separated from the other morphological parts of the plant and washed clean with water, air dried under shade for seven days pounded with pestle and mortar into fine particles. Based on its use in traditional african medicine, the antidiarrhoeal activity of the aqueous leaf extract of byrsocarpus coccineus, connaraceae, was evaluated on normal and castor oilinduced intestinal transit, castor oilinduced diarrhoea, enteropooling and gastric emptying. Phytochemical and antimicrobial screening of crude methanolic. Throughout popular knowledge, byrsocarpus coccineus. The antiinflammatory effect of the aqueous leaf extract of byrsocarpus coccineus was evaluated using the carrageenan and egg albumin induced rat paw edema, xylene induced mouse ear edema and formaldehyde induced arthritis inflammation tests. Pdf acute and subchronic toxicological assessment of. Byrsocarpus coccineus schum and thonn family connaraceae is one of.
We note the presence of saponosides, phenolic compounds, sterols and terpenes in the recipes studied. The plant with its delicate, pinktinged foliage, and white, sweetscented flowers has ornamental value. The need for enhanced efficacy and safety,and cheaper and more readily available new drugs has increased the search for new antidiabetic drugs from plants. Acute toxicity and invivo effects of leaf extracts of. Caesalpiniaceae synonyms, caesalpiniaceae antonyms.
This study was carried out to investigate the qualitative phytochemical analysis, invitro and invivo antioxidant property of the ethanolic extract of byrsocarpus coccineus leaves. Yoruba medicine history the medical traditions of the yoruba people of western nigeria developed within a culture that deeply respects and venerates ancestors. The fruit is a glabrous papery pod, usually containing one seed. Oral administration of eebc at 200, 400 and 800 mgkg significantly. Plants that are used as traditional medicine represent a relevant pool for selecting plant candidates that may have anticancer properties. Please note that this is a trial program and may end. Dpph free radical scavenging is used for determining antioxidant activities. And also thin layer chromatography tlc was carried out on the crude methanol extracts.
This study was designed to investigate the effect of the chemoprofiled hydroethanolic leaf extract of byrsocarpus coccineus in ethanol and sucroseinduced hypertension. Byrsocarpus coccineus schum and thonn is one of such plants that have been. Candidiasis in women of childbearing age is a major problem in most hospitals in nigeria. Full text pdf journal of applied pharmaceutical science. Therapeutic effects of byrsocarpus coccineus root bark. Diabetes mellitus is associated with significant morbidity and mortality worldwide. Hypoglycemic and antioxidant activities of the hydroethanolic leaf. The results of the antimicrobial screening showed that the ethyl acetate fraction at 200mgml produced zones of inhibition ranging from 22. Pharmacological and toxicological evaluation abidemi akindele, olufunmilayo adeyemi on. Antipyretic and antianemic activities of three antimalaria. Profiling of medicinal uses of byrsocarpus coccineusconnaraceae. These free radicals initiate lipid peroxidation by g2ccl4 1. A scandent shrub or liane of savanna thickets and secondary jungle, widely dispersed from guinea to west cameroons, and in other parts of tropical africa.
Application of treatments commenced four weeks after planting wap with a 2litre capacity handheld sprayer. The root bark powder of byrsocarpus coccineus was quantitatively analyzed for the presence of alkaloid, flavonoid, phenol, saponin and tannin according to the methods described by ordonez et al, 34 van burden and robinson 35 and skerget et al. The trachea was exposed and cannulated to ensure free and normal respiration. Byrsocarpus coccineus leaf decoction is used for the treatment of venereal diseases and as antidote to arrow poisoning and as remedy for pile, while the decoction of the whole plant is applied to swelling and tumours and also to arrest bleeding, the plant has also been reported as a remedy for diarrhea airdried leaves 37, 38 and 39 not tested. The results indicate that the solvent fractions of the whole plant extract of v. S department of biochemistry, lagos state university, ojo. Pdf the aqueous leaf extract of byrsocarpus coccineus schum and thonn. Connaraceae, a scandent shrub widely distributed in tropical africa, is used in ethnomedicine to manage many illnesses. Duckworth eminent scholar chair in drug research and development. Hepatoprotective and in vivo antioxidant effects of.
Connaraceae is a scandent shrub widely employed as a medicinal remedy for various. Byrsocarpus coccineus schum and thonn connaraceae is used in traditional medicine for treatment of various disease conditions, including diarrhea. Pdf acute and chronic toxicity studies of tubatuba. The extract administered orally at doses of 50, 100, 200 and 400 mgkg b. To validate the claim of the users, the analgesic effect of the aqueous leaf extract of the plant was studied in mice and rats using acetic acidinduced writhing, formalin, tail immersion, and coldwater tail flick pain tests. Byrsocarpus coccineus, candida, diabetes, fluconazole, malaria, phylogeny, typhoid. The antidiarrhea activity of the root bark aqueous extract of b.
Ameliorative effect of hydroethanolic leaf extract of. Since 1887, tristyly has been claimed repeatedly as typical of the connaraceae, with distyly and dioecism as derived conditions produced by sterilization of androecial or carpellary parts. Flavonoid glycoside from byrsocarpus coccineus leaves. Evaluation of the antidiarrhoeal activity of byrsocarpus. Based on its use in traditional african medicine, the antidiarrhoeal activity of the aqueous leaf extract of byrsocarpus coccineus, connaraceae, was evaluated on normal and castor oilinduced intestinal transit, castor oilinduced diarrhoea. Phytochemical screening investigation of this on the leaves of p. It is native to the deserts, scrub, and chaparral of the southwestern united states in arizona, california, and nevada, and in northwestern mexico. The leaf extracts of byrsocarpus coccineus was evaluated for antimicrobial activity using agar diffusion assay. Acute and subchronic toxicological assessment of byrsocarpus coccineus schum. Because of its odd electron, 2, 2 diphenylpicrylhydrazyl radical dpph gives a strong absorption band at 517nm in visible spectroscopy deep violet colour. The leaves contain apigenin, vitexin, isovitexin which along with other.
Patil, sunil satyappa jalalpure, screening of roots of baliospermum montanum for hepatoprotective activity against paracetamol induced liver damage in albino rats, international journal of green pharmacy,july 2010, 220223. Connaraceae aqueous leaf extract by a j akindele, k i nwumeh and o o adeyemi. Profiling of medicinal uses of byrsocarpus coccineus. But some plants produce phytanic acid and related acids this is evolutionarily interesting because membrane lipids from archaea use the terpenoid alcohols like phytanol and dip. Request pdf biological effects of byrsocarpus coccineus in vitro byrsocarpus coccineus schum. The total phenolic and flavonoid contents were also determined. Comparative study of the biological activity of allantoin and. Efficacy of spirulina platensis in improvement of the. To investigate the hepatoprotective and in vivo antioxidant effects of byrsocarpus coccineus in carbon tetrachloride ccl 4induced hepatotoxicity in rats.
Byrsocarpus coccineus schum and thonn is a climbing shrub found in west and central african countries including nigeria, ghana, cameroun, ivory coast, togo, central african and congo. The extract of the leaves of byrsocarpus coccineus also exhibited good cytotoxic activity against human breast adenocarcinoma cell lines bt549, bt20 and prostate adenocarcinoma cell line pc3 ic 50 18. Citrus limon l leaf and stem used traditionally for the treatment of diseases and infections was phytochemically and antimicrobially screened. As the electron becomes paired off in the presence of a free radical scavenger, the absorption varnishes, thus the resulting decolorization is stoictiometric. In northern nigeria, it is referred to by the hausas as tsamiyar kasa or kimbar maharba.
Apr 08, 20 the extract of the leaves of byrsocarpus coccineus also exhibited good cytotoxic activity against human breast adenocarcinoma cell lines bt549, bt20 and prostate adenocarcinoma cell line pc3 ic 50 18. In vitro anticancer screening of 24 locally used nigerian. Achillea millefolium duizendblad, schafgarbe, millefoglio, millefolium, yarrow, rojmari, biranjasif, rollike, cickafarkkoro. Isoniazid induced hepatotoxicity is a major concern in patients taking anti tuberculosis treatment and prophylaxis. Hypoglycemic and antioxidant activities of the hydroethanolic. Byrsocarpus coccineus, folium connraceae 105362 byrsocarpus coccineus, raidx connraceae 105361 cnestis ferruginea.
Plants remain a reliable source of efficacious and better tolerated drugs and botanicals. The leaf decoction for venereal diseases and as antidote to arrow poisoning in ghana. Antioxidant and antimicrobial activities of solvent fractions. The plant byrsocarpus coccineus is indigenous to africa especially togo, ghana and nigeria dalziel, 1955. Jatropha curcas is a plant that produces high oil content seeds used as biodiesel which is not edible because it contains toxic phorbol ester. Byrsocarpus coccineus have been shown to be useful in oropharngeal, dermatological, urogenital tract and haematological problems 610. Byrsocarpus coccineus schum and thonn is one of such plants that have been used in africa to treat different ailments including augmentation of labour. Efficacy of spirulina platensis in improvement of the reproductive performance and easing teratogenicity in hyperglycemic albino mice pranay punj pankaj department of zoology, nagaland university, lumami, nagaland, india.
Other fatty acids in the oil are those normally associated with seed lipids except for an unusually high proportion 12% ofcis11octadecenoic acid. Herbal treatments are the most popular form of traditional medicine and it is very rampant in the philippines since most of the filipinos prefer to be treated the old natural way. Access is allocated within two business days of purchase and lasts one year. The aqueous extract from byrsocarpus coccineus presented positive response in diminishing edemas and it can be used as an anti. The dpph free radical scavenging test in this study was conducted to evaluate the solvent fractions of v. Recent advances in herbal medicine for treatment of liver. Byrsocarpus coccineus connaraceae flavonols, glycosides ccl 4induced in vivo antioxidant effects akindele et al. African journal of microbiology research antifungal. Antidiarrhea activity of the aqueous root bark extract of.
Read lactobacillic and methylbranched olefinic acids in byrsocarpus coccineus seed oil, lipids on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. In this study, the ethnomedicinal approach was used to select several medicinal plants native to nigeria, on the basis of their local or traditional uses. Easy project materials website, free research project topics and materials. Easy project materials website, free research project topics. Plattner, and robert kleiman, northern regional research center, federal research, science and education administration, u. Pdf antioxidant and toxicological studies of ethanolic root extract. Preliminary phytochemical and antimicrobial screening of. Anxiolytic and sedative effects of byrsocarpus coccineus schum. Chinese journal of natural medicines cjnm, issn 20956975, original issn 16723651 was founded in may 2003 and is sponsored by china pharmaceutical university and chinese pharmaceutical association.
The phytoconstituents were qualitatively determined. The orishas, or gods of the yoruba, were former ancestors such as oduduwa, the legendary ancestor of all yoruba people, and his son ogun. This study was carried out to investigate the qualitative phytochemical analysis, invitro and invivo antioxidant property of the ethanolic extract of byrsocarpus coccineus. A decoction of leaves is drunk in ghana as a remedy for piles 8, and in nigeria for piles and flatulence. Anxiolytic and sedative effects of byrsocarpus coccineus. The present study aims to evaluate in vivo the acute toxicity, antipyretic and antianemic activities of three plant recipes used in the treatment of malaria in southern benin lake cities on wistar rats. Branched chain fatty acids mostly come from single celled organisms. Connaraceae is used in traditional medicine to treat several ailments in which reactive. Biological effects of byrsocarpus coccineus in vitro. What is an example for branched chain fatty acid from a. The aim of the study was to evaluate the phytochemicals and ameliorative effects of aqueous extracts of brysocarpus coccineus on serum liver enzymes in isoniazid inh induced hepatotoxicity in adult male wistar rats. Its cyclopropane ring structure has some properties of a double bond, and it may serve to regulate cell membrane fluidity. High vaginal swabs were analyzed for candida presence in women of child bearing age using chromogenic agar. Lactobacillic and methylbranched olefinic acids in.
Six kilograms of the powdered leaves of byrsocarpus coccineus was extracted by marceration with 6 l of n. Flavonoid glycosides from byrsocarpus coccineus leaves. The etiology of female infertility and recurrent pregnancy loss, in some women remains unclear and a scientific challenge. The fields of study are bacteriology, parasitology, pathology, virology, immunology, mycology, public health, biotechnology, meat science, nutrition, gynecology, surgery, genetics, prion diseases and epidemiology. Evaluation of quantitative phytochemicals, liver enzymes. Phytomonic acid is a saturated fatty acid found mainly in a gramnegative bacteria, l. Health information and publications in africa african. The tree grows to 48 meters in height, has grey or yellowish bark and compound leaves. Antiinflammatory activity of the aqueous leaf extract of. It can result in elevated serum liver enzymes and hepatic failure. Antioxidant and toxicological studies of ethanolic root extract of.
Antioxidants levels in female rats administered profertitility ethanolic leave extract of byrsocarpus coccineus oladimeji o. The aim of this study is to determine the acute toxicity and to screen the in vivo uterotonic effects of the ethylacetate leaf extract of byrsocarpus coccineus in pregnant rat uterus. The phytochemical screening of the crude methanol extract revealed the presence of saponins, terpenes. Silymarin also has significant antifibrotic activity. Pdf antipyretic activity of byrsocarpus coccineus schum and. Preliminary phytochemical and antimicrobial screening of the. Veterinary world publishes high quality and novelty papers focusing on veterinary and animal science. Heterostyly in the connaraceae with special reference to. The free radical scavenging activity was measured in terms of. Astragalus coccineus is a species of milkvetch known by the common name scarlet locoweed or scarlet milkvetch. Connaraceae is an angiosperm family that the species are distributed around tropical areas of the world and they are also. Antibacterial, allelopathic and antioxidant activity of.
A bioactivity versus ethnobotanical survey of medicinal. The use of traditional medicine as an alternative source of cure for many ailments has played an important role in health care delivery in both developing and developed countries. New leaves are accompanied by purple flowers on multibranched panicles. Pdf phytochemical constituents, thin layer chromatography. Pdf antiinflammatory effect of byrsocarpus coccineus schum. Analgesic activity of the aqueous leaf extract of byrsocarpus. This cited by count includes citations to the following articles in scholar. Duckworth eminent scholar chair in drug research and. The toxicity evaluation of the extracts revealed that they are practically nontoxic. The collected plants were then evaluated for cytoxicity.
Therapeutic effects of byrsocarpus coccineus root bark extract. This study was conducted to investigate the antidiabetic activity of the hydroethanolic leaf extract of b. Pdf hepatoprotective and in vivo antioxidant effects of. Evaluation of quantitative phytochemicals, liver enzymes and. Lonchocarpus laxiflorus is a species of legume in the family fabaceae.
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